Work Experience

  • Todate 2014

    Moleküler Biyoloji ve Genetik Bölüm Başkanı

    Yakın Doğu Üniversitesi Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümü

  • Todate 2010

    Tıbbi Genetik anabilim dalı başkanı

    Yakın Doğu Üniversitesi Tıp Fakültesi, Tıbbi Genetik anabilim dalı

  • 2011 2007

    Associate Professor

    University of Southern Denmark, Institute for Regional Health Services ( IRS ),Department of Clinical Genetics

  • 2007 2005

    Guest Associate Professor

    Aarhus University, Institute of Human Genetics

  • 2007 2005

    Assistant Professor

    University of Southern Denmark, Department of Anatomy and Neuroscience

  • 2003 2003

    Assistant Professor

    Aarhus University, Institute of Human Genetics

  • 2005 2003

    Associate Professor

    Aarhus University, Institute of Human Genetics

  • 2002 2002

    Assistant Professor

    Aarhus University, Institute of Human Genetics

  • 2002 2001

    Research Assistant Professor

    Cancercytogenetics laboratory Aarhus,Denmark, Aarhus Amtssygehus,Cancercytogenetics laboratory

  • 2000 1999

    Post-doctoral research fellow Danish Cancer Society

    Department of Cytogenetics in Aarhus, Department of Cytogenetics

  • 1998 1997

    Research Fellow at Danish Cancer Society

    Department of Cytogenetics Aarhus, Department of Cytogenetics

  • 1999 1994

    Research Fellow at Marmara University

    Maramara University/School of Medicine, Department of Medical Biology and Genetics

  • 1994 1992

    Research Scientist

    İstanbul School of Medicine, Department of Internal Medicine/Division of Medical GeneticsNad Prenatal Diagnosis Unit

Education & Training

  • Ph.D. 1999

    Tıbbi Biyoloji ve Genetik

    Marmara Ünivesitesi

  • Master1993

    Tıbbi Genetik

    İstenbul Üniversitesi, Çapa Tıp Fakültesi

  • Bachelor1992

    Biyoloji

    İstanbul universitesi

Honors, Awards and Grants

  • 2001
    Sister chromatid exchange frequency in B-cells stimulated by TPA in chronic lymphocytic leukemia
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  • 2004
    Adult human mesenchymal stem cell as a target for neoplastic transformation
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  • 2013
    KOAH Tedavi ve Prognozunda miRNA’ların Rolü
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  • 2015
    Mesenkim kök hücre ve kanser alanında yüksek katkı ödülü
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  • 1999
    Detection and sizing of telomeric repeat DNA in situ
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Research Projects

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    Region Syddanmarks Forskningspulje 2008, “Telomerforkortning og DNA-skader i lungevæv ved KOL”

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    6th Framework Programme (shared costs) 2004-2008: “Developing Molecular Medicines For Cancer In The Post-Genome Era”. Coordinator: Rob Newbold, London, UK.

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    İdiyopatik tekrarlayan gebelik kayıplarında telomer uzunluk dinamiği ve TRF1, TRF2, POT1 and TPP1 genlerinin ekspresyonun belirlenmesi 2015-16, Centre of excellence Araştırma Fonu, YDÜ

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    CENP-A Metilasyonu ve Topoizomeraz Aktivitesinin Düşüklerdeki Rolü 2015-16 Centre of excellence araştırma fonu, YDÜ

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    Grosseren M Brogaard og Hustrus Mindefond. 2005: Short and long term effect of gamma irradiation of adult human mesenchymal stem cells

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    Højberg fonden 2007: Telomere length as prognostic marker in lung cancers,

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    Danish Medical Research Council: Post-doc stipendium 2001-2002, Identification and characterization of expected telomerase inhibitor,

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    Danish Cancer Society: 2002-2005, Junior Stipend, the double-faced role of Telomeres in the development of mesenchymal tumors,

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    2- 6th Framework Programme 2003-2008: DNA damage responses, genomic instability and radiation-induced cancer: the problem of risk at low and protracted doses, RISK-RAD. Coordinator: Laure Sabatier, Paris, France.

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    Danish Research Agency: 2005: “Forskningsprogrammet for ikke-ioniserende stråling” Effects of non-ionizing radiation on neural development and mature brain. An experimental study employing human and rodent, organotypic brain slice cultures and neural stem cells. Shared cost, partner in joint project. Coordinator Jens Zimmer Rasmussen, SDU, Denmark.

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    Role of Angiotensin (1-7) on Reactive Oxygen Species (ROS) Damage Induced Telomere Shortening and Repair in Cardiovascular Disease and Hypertension, 2015-2016, Centre of Excellence Araştırma Proje Destek Fonu

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    Telomere shortening and DNA damage in pulmonary tissue from patients with chronic obstructive pulmonary disease (COPD) 2015-16 Centre of excellence araştırma fonu , YDÜ

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    Danish Medical Research Council: 2004, Delivery of telomerase-targeted gene therapy vectors to sites of tumour stroma formation by tumour-homing mesenchymal stem cell based carriers.

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    TUBİTAK 2011, co-applicant “The effect of TRF2 knockdown on radiosensitivity of human mesenchymal stem cells”

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    Region Syddanmarks Forskningspulje 2009, co-applicant “Telomere shortening in lung epithelial cells in patients with chronic obstructive pulmonary disease (COPD)”

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    5th Framework Programme 2002-2005: Telomeres and radiosensitivity of individuals. TELOSENS. Coordinator: Laure Sabatier, Paris, France.

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    4- 6th Framework Programme, BIOACE, Coordinator Sukran Vardar, Izmir, Turkey

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Molecular Cytogenetic Applications in Diagnostics and Research: An Overview

Book Chapter Springer-Verlag Berlin Heidelberg, Volume 18, Issue Chapter 1, 2009, Pages 1-6

Abstract

The development of normal (Caspersson et al. 1968, 1971) and “high-resolution” banding of chromosomes (Yunis et al. 1983) made it possible to identify chromo- somal anomalies like deletions, duplications, inversions and translocations with a resolution down to about 5 × 106 number of chromosome defects. However, in a number of situations, chromosome aberrations are too small or too complex to be fully diagnosed by banding techniques. Therefore, more sensitive and more refined techniques are sometimes necessary. This need has been met to some extent through the development of in situ hybridization (ISH) techniques. In addition to refining the banding technique, ISH is the only method that can simultaneously give information at both molecular and cellular levels, namely by visualizing DNA sequences on chromosomes and in cells and tissue sections, thereby enabling specific nucleic acid sequences to be visualized in their natural biological microenvironment. As a consequence, ISH has found a number of applications in clinical diagnosis and research. base pairs, and this enabled the diagnosis of a...


Özet

kitap bölümü

Transformation of Mesenchymal Stem Cells

Book Chapter Publisher InTech, Volume 11, Issue Chapter11, 2011, Pages 207-226

Abstract

Over the last thirty years, the foremost inspiration for research on metastasis, cancer recurrence, and increased resistance to chemo- and radiotherapy has been the notion of cancer stem cells.The twenty-eight chapters assembled in Cancer Stem Cells - The Cutting Edge summarize the work of cancer researchers and oncologists at leading universities and hospitals around the world on every aspect of cancer stem cells, from theory and models to specific applications (glioma), from laboratory research on signal pathways to clinical trials of bio-therapies using a host of devices, from solutions to laboratory problems to speculation on cancersâ€TM stem cellsâ€TM evolution. Cancer stem cells may or may not be a subset of slowly dividing cancer cells that both disseminate cancers and defy oncotoxic drugs and radiation directed at rapidly dividing bulk cancer cells, but research on cancer stem cells has paid dividends for cancer prevention, detection, targeted treatment, and improved prognosis.


Özet

kitap bölümü

Progressive Multifocal Leukoencephalopathy in Chronic Lymphocytic Leukemia: A Case Report and Review of Literature

Case Report Turkiye Klinikleri Journal of Case Reports, Volume 2, Issue 23, 2015, Pages 136-140

Abstract

Progressive multifocal leukoencephalopathy (PML) is an infectious demyelinating disease of the central nervous system caused by the JC virus, a DNA polyomavirus. PML occurs during reactivation of the latent JC virus after long-standing immunosuppression. It is usually associated with conditions causing profound immunodeficiency, classically seen in patients with AIDS. Second commonly it has been reported in lymphoproliferative disorders like chronic lymphocytic leukemia (CLL). Here we report a case of 72 years old female patient with CLL who developed PML. Her clinical symptoms were rapid progressive slight hemiparesis of the right side and aphasia. In cranial MRI, a typical subcortical demyelinating nonenhancing lesions was shown, and JC virus DNA was positive in the CSF by PCR.


Özet

Progresif multifokal lökoensefalopati (PML), bir DNA polyomavirüs olan JC virüs tarafından oluşturulan, santral sinir sisteminin enfeksiyöz demiyelinizan bir hastalığıdır. PML, latent JC virüsün uzun süreli immünsüpresyon sonrasında reaktivasyonu sırasında oluşur. Genelde belirgin immünsüpresyona yol açan durumlar ile ilişkilidir ve klasik olarak da edinilmiş immün yetmezlik sendromu (AIDS) hastalarında görülür. İkinci sıklıkla da kronik lenfositik lösemi (KLL) gibi lenfoproliferatif hastalıklarla bildirilmektedir. Burada, 72 yaşında KLL’ye sahip olan ve PML geliştiren bir kadın hasta rapor edilmektedir. Hastanın klinik semptomları hızlı ilerleyici sağ taraflı hemiparezi ve afaziydi. Beyin manyetik rezonans görüntüleme (MRG), tipik subkortikal demiyelinizan kontrast tutmayan beyaz cevher lezyonlarını göstermekteydi ve beyin omurilik sıvısı (BOS) JC virüs DNA PCR’ı pozitif saptandı.

http://www.nature.com/nbt/journal/v20/n6/full/nbt0602-592.html

General Publication Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells, 2016

Abstract


Özet

https://www.futuremedicine.com/doi/full/10.2217/17460751.1.1.125

General Publication Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell, 2016

Abstract


Özet

http://www.sciencedirect.com/science/article/pii/S095980490600205X

General Publication Therapeutic potential of adult stem cells, 2016

Abstract


Özet

http://www.nature.com/onc/journal/v23/n29/abs/1207651a.html

General Publication Adult human mesenchymal stem cell as a target for neoplastic transformation, 2016

Abstract


Özet

https://gigascience.biomedcentral.com/articles/10.1186/s13742-015-0066-5

General Publication The ocean sampling day consortium, 2016

Abstract


Özet

http://www.karger.com/Article/Fulltext/15339

General Publication Telomeric repeat organization—a comparative in situ study between man and rodent, 2016

Abstract


Özet

http://www.sciencedirect.com/science/article/pii/S1568786412001358

General Publication Telomere dynamics in human mesenchymal stem cells after exposure to acute oxidative stress, 2016

Abstract


Özet

http://www.nature.com/onc/journal/v28/n43/abs/onc2009238a.html

General Publication A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT, 2016

Abstract


Özet

http://www.futuremedicine.com/doi/abs/10.2217/17460751.3.6.849

General Publication Transformation of human mesenchymal stem cells in radiation carcinogenesis: long-term effect of ionizing radiation, 2016

Abstract


Özet

http://onlinelibrary.wiley.com/doi/10.1002/0471747599.cac018/full

General Publication Transformation and Immortalization, 2016

Abstract


Özet

https://bmchematol.biomedcentral.com/articles/10.1186/1471-2326-4-3

General Publication A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria, 2016

Abstract


Özet

http://www.sciencedirect.com/science/article/pii/S0014482707000067

General Publication Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart, 2016

Abstract


Özet

http://www.biomedcentral.com/1471-2199/8/49/

General Publication Mesenchymal stem cells with high telomerase expression do not actively restore their chromosome arm specific telomere length pattern after exposure to ionizing radiation, 2016

Abstract


Özet

https://www.researchgate.net/profile/Nedime_Serakinci2/publication/51881242_Prognostic_role_of_sensitive-to-apoptosis_gene_expression_in_rectal_cancer/links/02e7e52664bef6cd05000000.pdf

General Publication Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer, 2016

Abstract


Özet

http://www.sciencedirect.com/science/article/pii/S0165460800003009

General Publication Sister chromatid exchange frequency in B-cells stimulated by TPA in chronic lymphocytic leukemia, 2016

Abstract


Özet

http://online.liebertpub.com/doi/abs/10.1089/cbr.2011.1024

General Publication Mesenchymal stem cells as therapeutic delivery vehicles targeting tumor stroma, 2016

Abstract


Özet

https://www.researchgate.net/profile/Nedime_Serakinci2/publication/13238706_Detection_and_sizing_of_telomeric_repeat_DNA_in_situ/links/541961940cf25ebee988521d.pdf

General Publication Detection and sizing of telomeric repeat DNA in situ, 2016

Abstract


Özet

http://www.sciencedirect.com/science/article/pii/S0959804914001737

General Publication Mesenchymal stem cells, cancer challenges and new directions, 2016

Abstract


Özet

http://www.sciencedirect.com/science/article/pii/S0378111913010184

General Publication Association of leptin receptor gene Q223R polymorphism on lipid profiles in comparison study between obese and non-obese subjects, 2016

Abstract


Özet

http://www.sciencedirect.com/science/article/pii/S0300908407002477

General Publication Telomere stability and telomerase in mesenchymal stem cells, 2016

Abstract


Özet

http://link.springer.com/protocol/10.1007/978-3-540-70581-9_1

General Publication Molecular cytogenetic applications in diagnostics and research: an overview, 2016

Abstract


Özet

http://journals.tubitak.gov.tr/medical/abstract.htm?id=4132

General Publication Telomeric repeats of immortal hamster cells, 2016

Abstract


Özet

http://www.sciencedirect.com/science/article/pii/S0378111915008604

General Publication Near East University Genetic Mutation Database (NEU-GD): The first mutation database of Northern Cyprus, 2016

Abstract


Özet

http://www.ingentaconnect.com/contentone/ben/cscr/2016/00000011/00000004/art00007

General Publication Double-Faced Role of Human Mesenchymal Stem Cells and their Role/Challenges in Cancer Therapy, 2016

Abstract


Özet

General Publication A late onset tremor and ataxia syndrome; FXTAS and its ignored peripheral nervous system findings in diagnostic criteria, 2016

Abstract


Özet

http://www.dl.begellhouse.com/journals/6dbf508d3b17c437,48fcfe1d06fc1851,6782da8312c56356.html

General Publication The Route to HPV-Associated Neoplastic Transformation: A Review of the Literature, 2016

Abstract


Özet

http://www.wjgnet.com/1007-9327/full/v17/i44/4905.htm

General Publication Citation of This Article, 2016

Abstract


Özet

http://www.tandfonline.com/doi/abs/10.3109/19396368.2015.1109007

General Publication A unique mosaic Turner syndrome patient with androgen receptor gene derived marker chromosome, 2016

Abstract


Özet

http://jcmtjournal.com/article/view/1533

General Publication The role of human papillomaviruses in cancer progression, 2016

Abstract


Özet

https://www.infona.pl/resource/bwmeta1.element.elsevier-604d7a46-0e9a-304a-9230-74014af60c08

General Publication 423: Epigenetic effects of radiation on hTERT-immortalized mesenchymal stem cells, 2016

Abstract


Özet

http://www.sciencedirect.com/science/article/pii/S1769721205000297

General Publication A different approach to telomere analysis with ddPRINS in chronic lymphocytic leukemia, 2016

Abstract


Özet

http://www.degruyter.com/view/j/tjb.2016.41.issue-1/tjb-2016-0001/tjb-2016-0001.xml

General Publication Association between leptin G-2548A gene polymorphism, plasma leptin levels and lipid profiles in Turkish Cypriot obese subjects/Kıbrıslı Türk obez kişilerde leptin G-2548A gen polimorfizmi ile plazma leptin seviyeleri ve lipid profili arasındaki ilişki, 2016

Abstract


Özet

http://www.dl.begellhouse.com/journals/6dbf508d3b17c437,48fcfe1d06fc1851,4ac6e04801832ee2.html

General Publication Human Mesenchymal Stem Cells in Cancer Therapy, 2016

Abstract


Özet

http://www.ejcancer.com/article/S0959-8049(14)50223-7/abstract

General Publication 253: Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients, 2016

Abstract


Özet

http://www.sciencedirect.com/science/article/pii/S0141813015300751

General Publication Partial knockdown of TRF2 increase radiosensitivity of human mesenchymal stem cells, 2016

Abstract


Özet

http://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-3-11

General Publication Telomerase activity in human leukemic cells with or without monosomy 7 or 7q, 2016

Abstract


Özet

https://www.futuremedicine.com/doi/full/10.2217/17460751.2.6.957

General Publication Road for understanding cancer stem cells: model cell lines, 2016

Abstract


Özet

http://biolres.biomedcentral.com/articles/10.1186/0717-6287-47-61

General Publication Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients, 2016

Abstract


Özet

http://www.karger.com/Article/Abstract/56899

General Publication Expansion of repetitive DNA into cytogenetically visible elements, 2016

Abstract


Özet

http://www.academia.edu/download/40529608/Turkiye_klimikleri_kronik_lenfositik_losemi_NS_2.pdf

General Publication Kronik Lenfositik Lösemide Progresif Multifokal Lökoensefalopati: Olgu Sunumu ve Literatürün Gözden Geçirilmesi, 2016

Abstract


Özet

http://link.springer.com/chapter/10.1007/978-94-017-7273-0_14

General Publication Mesenchymal Stem Cells in Cancer Therapy, 2016

Abstract


Özet

http://www.sciencedirect.com/science/article/pii/S0165460802005332

General Publication Multiple telomeric aberrations in a telomerase-positive leukemia patient, 2016

Abstract


Özet

http://www.forskningsdatabasen.dk/en/catalog/2185852386

General Publication Telomerase activity in human leukemic cells with and without monosomy 7 and 7q, 2016

Abstract


Özet

General Publication InTech-Transformation of Mesenchymal Stem Cells, 2016

Abstract


Özet

General Publication Trasnsformation and Immortalization, 2016

Abstract


Özet

http://scholar.google.com/scholar?cluster=720759199483899170&hl=en&oi=scholarr

General Publication In vivo over-expression of circulating Dlk1/Pref-1 protein using hydrodynamic-based gene transfer leads to lower bone mass with marked effects on trabecular bone micro-architecture., 2016

Abstract


Özet

http://scholar.google.com/scholar?cluster=12763221774821159228&hl=en&oi=scholarr

General Publication In vivo overexpression of circulating DlkJ/Pref-1 protein leads to increased bone turnover and decreased bone mass, 2016

Abstract


Özet

General Publication Molecular. Cytogenetic. Applications. in. Diagnostics. and. Research: An. Overview. N, 2016

Abstract


Özet

http://link.springer.com/10.1007/978-3-642-16483-5_125

General Publication Adult Stem Cells, 2016

Abstract


Özet

http://www.forskningsdatabasen.dk/en/catalog/2282318173

General Publication Molecular cytogenetic applications in diagnostics and research, 2016

Abstract


Özet

General Publication Transformation an immortalization, 2016

Abstract


Özet

http://www.intechopen.com/source/pdfs/17332/InTech-Transformation_of_mesenchymal_stem_cells.pdf

General Publication Transformation of Mesenchymal Stem Cells, 2016

Abstract


Özet

http://www.noropsikiyatriarsivi.com/sayilar/433/buyuk/92-931.pdf

General Publication Late Onset Tremor and Ataxia Syndrome: FXTAS and its Ignored Peripheral Nervous System Findings in Diagnostic Criteria, 2016

Abstract


Özet

http://www.forskningsdatabasen.dk/en/catalog/2194035786

General Publication Immortalization of human stem and primary cells by telomerase, 2016

Abstract


Özet

http://scholar.google.com/scholar?cluster=18103748061157936601&hl=en&oi=scholarr

General Publication Ectopic telomerase expression elongates telomeres while maintaining osteogenic potential of bone marrow stromal cells, 2016

Abstract


Özet

http://scholar.google.com/scholar?cluster=821531001728604600&hl=en&oi=scholarr

General Publication The use of FISH/M-FISH in patients with hematological malignancies for further characterization chromosomal abnormalities detected on conventional cytogenetic analysis, 2016

Abstract


Özet

General Publication Cancer Stem Cells, 2016

Abstract


Özet

General Publication Adult Stem Cells, 2016

Abstract


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General Publication Transformation and immortalization, 2016

Abstract


Özet

http://scholar.google.com/scholar?cluster=17399853122775962005&hl=en&oi=scholarr

General Publication Role of telomeres in cancer progression and aging, 2016

Abstract


Özet

General Publication Essay in Encyclopedia of Cancer, 2016

Abstract


Özet

http://scholar.google.com/scholar?cluster=18358137186658300100&hl=en&oi=scholarr

General Publication Detection and Sizing of Human Chromosomal Telomeres by ddPrins-Primed in situ Staining, 2016

Abstract


Özet

http://scholar.google.com/scholar?cluster=2650376605073968372&hl=en&oi=scholarr

General Publication Do chromosome 1, 9, 16 and Y heteromorphisms increase the risk of recurrent abortion?, 2016

Abstract


Özet

http://www.springerlink.com/index/n146n606461k2h66.html

General Publication Therapeutic Potential, 2016

Abstract


Özet

http://scholar.google.com/scholar?cluster=3393734247122704181&hl=en&oi=scholarr

General Publication A case of Turner syndrome with a rare reciprocal translocation between an autosome and the X chromosome, 2016

Abstract


Özet

http://www.dl.begellhouse.com/pt/download/article/7a114ec31c2b229b/Contents.pdf

General Publication Eukaryotic Gene Expression, 2016

Abstract


Özet

http://scholar.google.com/scholar?cluster=8006325396821729426&hl=en&oi=scholarr

General Publication A case of mental retardation associated with a partial tetrasomy of chromosome 15, 2016

Abstract


Özet

http://www.muni.cz/research/publications/234411

General Publication Telomeric repeat organization-a comparative in situ study between man and rodent, 2016

Abstract


Özet

Late onset tremor and ataxia syndrome: FXTAS and its ignored peripheral nervous system findings in diagnostic criteria

Letter to the Editor Nöropsikiyatri Arşivi, Volume 53, Issue 1, 2016, Pages 89-90

Abstract

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Özet

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Telomeric repeat organization—a comparative in situ study between man and rodent

Original Article Cytogenetic and Genome Research, Volume *, Issue -, 1999, Pages -

Abstract

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Özet

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Detection and sizing of telomeric repeat DNA in situ

Original Article Nedime Serakinci, Jørn Koch, Volume *, Issue -, 1999, Pages -

Abstract

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Özet

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Sister chromatid exchange frequency in B-cells stimulated by TPA in chronic lymphocytic leukemia

Original Article Cancer genetics and cytogenetics, Volume *, Issue -, 2000, Pages -

Abstract

-


Özet

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Expansion of repetitive DNA into cytogenetically visible elements

Original Article Cytogenetic and Genome Research, Volume *, Issue -, 2001, Pages -

Abstract

-


Özet

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Telomerase activity in human leukemic cells with or without monosomy 7 or 7q

Original Article BMC medical genetics, Volume *, Issue -, 2002, Pages -

Abstract

-


Özet

-

Telomerase activity in human leukemic cells with and without monosomy 7 and 7q

Original Article BMC Med Genetics, Volume *, Issue -, 2002, Pages -

Abstract

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Özet

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Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells

Original Article Nature biotechnology, Volume *, Issue -, 2002, Pages -

Abstract

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Özet

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Multiple telomeric aberrations in a telomerase-positive leukemia patient

Original Article Cancer genetics and cytogenetics, Volume *, Issue -, 2002, Pages -

Abstract

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Özet

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Adult human mesenchymal stem cell as a target for neoplastic transformation

Original Article Oncogene, Volume *, Issue -, 2004, Pages -

Abstract

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Özet

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A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria

Original Article BMC Hematology, Volume *, Issue -, 2004, Pages -

Abstract

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Özet

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A different approach to telomere analysis with ddPRINS in chronic lymphocytic leukemia

Original Article European journal of medical genetics, Volume *, Issue -, 2006, Pages -

Abstract

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Özet

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Therapeutic potential of adult stem cells

Original Article European Journal of cancer, Volume *, Issue -, 2006, Pages -

Abstract

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Özet

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Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart

Original Article Experimental cell research, Volume *, Issue -, 2007, Pages -

Abstract

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Özet

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Mesenchymal stem cells with high telomerase expression do not actively restore their chromosome arm specific telomere length pattern after exposure to ionizing radiation

Original Article BMC molecular biology, Volume *, Issue -, 2007, Pages -

Abstract

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Özet

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Telomere stability and telomerase in mesenchymal stem cells

Original Article Biochimie, Volume *, Issue -, 2008, Pages -

Abstract

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Özet

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A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT

Original Article Oncogene, Volume *, Issue -, 2009, Pages -

Abstract

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Özet

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Adult Stem Cells

Original Article Encyclopedia of Cancer, Volume *, Issue -, 2011, Pages -

Abstract

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Mesenchymal stem cells as therapeutic delivery vehicles targeting tumor stroma

Original Article Cancer Biotherapy and Radiopharmaceuticals, Volume *, Issue -, 2011, Pages -

Abstract

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Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer

Original Article World journal of gastroenterology: WJG, Volume *, Issue -, 2011, Pages -

Abstract

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Özet

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Telomere dynamics in human mesenchymal stem cells after exposure to acute oxidative stress

Original Article DNA repair, Volume *, Issue -, 2012, Pages -

Abstract

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Özet

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Telomere dynamics in human mesenchymal stem cells after exposure to acute oxidative stress.

Original Article Elsevier/, Volume 9, Issue 11, 2012, Pages 774-779

Abstract

A gradual shortening of telomeres due to replication can be measured using the standard telomere restriction fragments (TRF) assay and other methods by measuring the mean length of all the telomeres in a cell. In contrast, stress-induced telomere shortening, which is believed to be just as important for causing cellular senescence, cannot be measured properly using these methods. Stress-induced telomere shortening caused by, e.g. oxidative damage happens in a stochastic manner leaving just a few single telomeres critically short. It is now possible to visualize these few ultra-short telomeres due to the advantages of the newly developed Universal single telomere length assay (STELA), and we therefore believe that this method should be considered the method of choice when measuring the length of telomeres after exposure to oxidative stress. In order to test our hypothesis, cultured human mesenchymal stem cells, either primary or hTERT immortalized, were exposed to sub-lethal doses of hydrogen peroxide, and the short term effect on telomere dynamics was monitored by Universal STELA and TRF measurements. Both telomere measures were then correlated with the percentage of senescent cells estimated by senescence-associated ß-galactosidase staining. The exposure to acute oxidative stress resulted in an increased number of ultra-short telomeres, which correlated strongly with the percentage of senescent cells, whereas a correlation between mean telomere length and the percentage of senescent cells was absent. Based on the findings in the present study, it seems reasonable to conclude that Universal STELA is superior to TRF in detecting telomere damage caused by exposure to oxidative stress. The choice of method should therefore be considered carefully in studies examining stress-related telomere shortening as well as in the emerging field of lifestyle studies involving telomere length measurements.


Özet

makale

Association of leptin receptor gene Q223R polymorphism on lipid profiles in comparison study between obese and non-obese subjects

Original Article Gene, Volume *, Issue -, 2013, Pages -

Abstract

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Özet

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Association of leptin receptor gene Q223R polymorphism on lipi profiles in comparison study between obese and non-obese subjects

Original Article Gene/Elsevier, Volume 1, Issue 529, 2013, Pages 16-20

Abstract

Objectives Leptin is a hormone secreted from adipocytes. It regulates metabolism and energy homeostasis through the leptin receptor (LEPR) which is localized centrally in hypothalamus as well as in peripheral tissues. The aim of this study was to investigate the association of leptin receptor gene Q223R polymorphism on obesity in association with body mass index (BMI), lipid parameters, plasma leptin levels and homeostasis model assessment of insulin resistance (HOMA-IR). Design and methods The study included 110 obese and 90 non-obese subjects. The LEPR Q223R polymorphism was determined by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). Plasma leptin levels, serum lipid and antropometric parameters were measured. Results No association was found between LEPR gene Q223R polymorphism and BMI in both study and control groups. Strikingly study group with non-obese subjects and with the RR genotype (homozygous mutant) had significantly higher serum total cholesterol (p < 0.001) and low density lipoprotein cholesterol (LDL-cholesterol) levels (p < 0.05) than QR (heterozygous) and QQ (wild type) genotypes. In obese group, subjects with the RR genotypes had significantly higher triglycerides (p < 0.05) levels, waist (p < 0.05) and hip circumferences (p < 0.001) than the QQ and QR genotypes. Conclusions Our results suggest that the LEPR gene Q223R polymorphism has an association with waist and hip circumferences in obese group but no direct association with obesity although there is a significant influence on lipid profile both in obese and non-obese subjects. Abbreviations LEPR, leptin receptor; BMI, body mass index; HOMA-IR, homeostasis model assessment of insulin resistance; PCR–RFLP, polymerase chain reaction–restriction fragment length polymorphism; LDL-C, low density lipoprotein cholesterol; SNPs, single nucleotide polymorphisms; HMG-CoA reductase, 3-hydroxy-3-methylglutaryl coenzyme reductase; VLDL, very-low density lipoprotein; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; ELISA, enzyme-linked immunosorbent assay; ANOVA, analysis of variance; ApoB, apolipoprotein B


Özet

makale

Mesenchymal stem cells, cancer challenges and new directions

Original Article European Journal of Cancer, Volume *, Issue -, 2014, Pages -

Abstract

-


Özet

-

Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients

Original Article Biological research, Volume *, Issue -, 2014, Pages -

Abstract

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Özet

-

253: Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients

Original Article European Journal of Cancer, Volume *, Issue -, 2014, Pages -

Abstract

-


Özet

-

423: Epigenetic effects of radiation on hTERT-immortalized mesenchymal stem cells

Original Article European Journal of Cancer, Volume *, Issue -, 2014, Pages -

Abstract

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Özet

-

The ocean sampling day consortium

Original Article GigaScience, Volume *, Issue -, 2015, Pages -

Abstract

-


Özet

-

Kronik Lenfositik Lösemide Progresif Multifokal Lökoensefalopati: Olgu Sunumu ve Literatürün Gözden Geçirilmesi

Original Article Turkiye Klinikleri Journal of Case Reports, Volume *, Issue -, 2015, Pages -

Abstract

-


Özet

-

Near East University Genetic Mutation Database (NEU-GD): The first mutation database of Northern Cyprus

Original Article Gene, Volume *, Issue -, 2015, Pages -

Abstract

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Özet

-

A late onset tremor and ataxia syndrome; FXTAS and its ignored peripheral nervous system findings in diagnostic criteria

Original Article Archives of Neuropsychiatry, Volume *, Issue -, 2015, Pages -

Abstract

-


Özet

-

Near East University Genetic Mutation Database (NEU-GD): The first mutation database of Northern Cyprus

Original Article ELSEVIER/GENE, Volume 571 (1), Issue Gene 571 (2015), 2015, Pages 145-148

Abstract

The health care system is negatively affected by the genetic disorders that lead to an increasing rate of morbidity and neonatal deaths and affect adults as well. These create a substantial government's psychosocial and economic burden on clinicians, patients and their families with the advancement in the field of genetics. There has been a tremendous increase in the rate in which diseases associated with variant DNA sequences are being sought and identified. The goal behind the creation of Near East University Genetic Mutation Database (NEU-GD) is to map and apprehend the patterns of common genetic diversity in the human genetic makeup in order to accelerate the search for the genetic causes of human disease. NEU-GD will allow scientists to generate extraordinarily useful information such as allelic variations among pop- ulation, and description of the genetic blueprint of mutations occurring in human beings. In this communication we report the construction of the first genetic mutation database for the people belonging to different ethnic groups living in North Cyprus (http://genetics-db.neu.edu.tr/). Therefore NEU-GD can serve as an important tool available online for molecular genetic testing of inherited disorder and persuade for further in- vestigation of novel genetic disorders in North Cyprus population.


Özet

Partial knockdown of TRF2 increase radiosensitivity of human mesenchymal stem cells

Original Article ELSEVIER/International Journal of Biological Macromolecules, 2015, Pages 1-6

Abstract

Telomere repeat binding factor TRF2 is a member of shelterin complex with an important role in pro- tecting and stabilizing chromosomal ends. In the present study, we investigated the effect of partial knockdown of TRF2 on radiosensitivity of telomerase immortalized human mesenchymal stem cells (hMSC-telo1), which have a higher radioresistance compared to non telomerized counterpart. Partial knockdown of the protein achieved 15–20% reduction in TRF2 protein levels. The study compared the effect of 2.5 Gy radiation in two–four days after irradiation for hMSC-telo1 cells and the cells transfected with siTRF2 and null control vector. Radio-response of the cells were examined using senescence asso- ciated -Gal assay (-Gal), colony forming assay (CFU) and -H2AX phosphorylation. TRF2 deficiency substantially increased radiosensitivity of cells compared to controls in both proliferation and senes- cence assay (2.4 fold increase in -Gal, 1.6 fold decrease in CFU). In addition, it increased the -H2AX foci as revealed by both immunfluorescence and Western blot analysis. Our data suggests that partial knock- down of TRF2 in hMSC-telo1 cells cause increased -H2AX foci which led to fail TRF2 to protect telomeres from radiation thus TRF2 deficiency led to a 1,5–2 fold increase in the radiosensitivity of hMSC-telo1 cells through telomere destabilization.


Özet

Human mesenchymal stem cells in cancer therapy

Original Article Critical Reviews™ in Eukaryotic Gene Expression., Volume -, Issue -, 2015, Pages -

Abstract

-


Özet

-

Association between leptin G-2548A gene polymorphism, plasma leptin levels and lipid profiles in Turkish Cypriot obese subjects

Original Article Turkish Journal of Biochemistry, Volume 41, Issue 1, 2016, Pages 1-8

Abstract

Objective: Leptin (LEP) is a metabolic and neuroendocrine hormone which is present in the circulation in amounts proportional to fat mass that acts to reduce food intake and increase energy expenditure thereby regulating body weight homeostasis. Various polymorphisms are shown to be present in LEP gene which play important roles in obesity and obesity-related metabolic biomarkers. The aim of this study was to investigate the association of one of these polymorphisms, leptin gene G-2548A polymorphism, on obesity in association with body mass index (BMI), lipid parameters, plasma leptin levels and homeostasis model assessment of insulin resistance (HOMA-IR).


Özet

A unique mosaic Turner syndrome patient with androgen receptor gene derived marker chromosome

Original Article Taylor and Francis(Taylor and Francis Group)/Systems Biology in Reproductive Medicine, Volume 62, Issue 1, 2016, Pages 77-83

Abstract

Patients with Turner syndrome are generally characterized by having short stature with no secondary sexual characteristics. Some abnormalities, such as webbed neck, renal malformations (450%) and cardiac defects (10%) are less common. The intelligence of these patients is considered normal. Non-mosaic monosomy X is observed in approximately 45% of postnatal patients with Turner syndrome and the rest of the patients have structural abnormalities or mosaicism involving 46,X,i(Xq), 45,X/46,XX, 45,X and other variants. The phenotype of 45,X/ 46,X,+mar individuals varies by the genetic continent and degree of the mosaicism. The gene content of the marker chromosome is the most important when correlating the phenotype with the genotype. Here we present an 11-year-old female who was referred for evaluation of her short stature and learning disabilities. Conventional cytogenetic investigation showed a mosaic 45,X/46,X,+mar karyotype. Fluorescence in situ hybridization showed that the marker chromosome originated from the X chromosome within the androgen receptor (AR) and X-inactive specific transcript (XIST) genes. Therefore, it is possible that aberrant activation of the marker chromosome, compromising the AR and XIST genes, may modify the Turner syndrome phenotype.


Özet

Partial knockdown of TRF2 increase radiosensitivity of human mesenchymal stem cells

Original Article international journal of biological macromolecules, Volume 90, Issue -, 2016, Pages 53-58

Abstract

Telomere repeat binding factor TRF2 is a member of shelterin complex with an important role in protecting and stabilizing chromosomal ends. In the present study, we investigated the effect of partial knockdown of TRF2 on radiosensitivity of telomerase immortalized human mesenchymal stem cells (hMSC-telo1), which have a higher radioresistance compared to non telomerized counterpart. Partial knockdown of the protein achieved 15–20% reduction in TRF2 protein levels. The study compared the effect of 2.5 Gy radiation in two–four days after irradiation for hMSC-telo1 cells and the cells transfected with siTRF2 and null control vector. Radio-response of the cells were examined using senescence associated ß-Gal assay (ß-Gal), colony forming assay (CFU) and ?-H2AX phosphorylation. TRF2 deficiency substantially increased radiosensitivity of cells compared to controls in both proliferation and senescence assay (2.4 fold increase in ß-Gal, 1.6 fold decrease in CFU). In addition, it increased the ?-H2AX foci as revealed by both immunfluorescence and Western blot analysis. Our data suggests that partial knockdown of TRF2 in hMSC-telo1 cells cause increased ?-H2AX foci which led to fail TRF2 to protect telomeres from radiation thus TRF2 deficiency led to a 1,5–2 fold increase in the radiosensitivity of hMSC-telo1 cells through telomere destabilization. © 2015 Elsevier B.V.


Özet

Partial knockdown of TRF2 increase radiosensitivity of human mesenchymal stem cells

Original Article International Journal of Biological Macromolecules, Volume 90, Issue -, 2016, Pages 53-58

Abstract

Telomere repeat binding factor TRF2 is a member of shelterin complex with an important role in protecting and stabilizing chromosomal ends. In the present study, we investigated the effect of partial knockdown of TRF2 on radiosensitivity of telomerase immortalized human mesenchymal stem cells (hMSC-telo1), which have a higher radioresistance compared to non telomerized counterpart. Partial knockdown of the protein achieved 15–20% reduction in TRF2 protein levels. The study compared the effect of 2.5 Gy radiation in two–four days after irradiation for hMSC-telo1 cells and the cells transfected with siTRF2 and null control vector. Radio-response of the cells were examined using senescence associated ß-Gal assay (ß-Gal), colony forming assay (CFU) and ?-H2AX phosphorylation. TRF2 deficiency substantially increased radiosensitivity of cells compared to controls in both proliferation and senescence assay (2.4 fold increase in ß-Gal, 1.6 fold decrease in CFU). In addition, it increased the ?-H2AX foci as revealed by both immunfluorescence and Western blot analysis. Our data suggests that partial knockdown of TRF2 in hMSC-telo1 cells cause increased ?-H2AX foci which led to fail TRF2 to protect telomeres from radiation thus TRF2 deficiency led to a 1,5–2 fold increase in the radiosensitivity of hMSC-telo1 cells through telomere destabilization.


Özet

-

Mesenchymal stem cells, cancer challenges and new directions

Review Elsevier/European Journal of Cancer, Volume 8, Issue 50, 2014, Pages 22-30

Abstract

Therapeutic use of multipotent mesenchymal stromal stem cells (MSC) is a promising venue for a large number of degenerative diseases and cancer. Their availability from many different adult tissues, ease of expansion in culture, the ability to avoid immune rejection and their homing ability, are some of the properties of MSCs that make them a great resource for therapy. However, the challenges and risks for cell-based therapies are multifaceted. The blessing of cell culture expansion also comes with a burden. During in vitro expansion, stem cells experience a long replicative history and therefore, become subjected to damage from intracellular and extracellular influences. As previously shown cells that are manipulated to obtain an expanded replicative potential are prone to spontaneous transformation in culture. These manipulations help bypass the naturally built-in controls of the cell that govern the delicate balance between cell proliferation, senescence and carcinogenesis. Because of this, there is a risk for patients receiving stem cells that are in vitro expanded. Whether these cells are genetically engineered or harbouring xenogenic compounds, they cannot truly be considered "safe" unless the cells are closely monitored. In the present communication, we will focus on the therapeutic potential of the human mesenchymal stem cells (hMSC) with special focus on their use in cancer therapy. We will consider different mechanisms, by which stem cells can maintain telomeres and thereby the cell's ability to be expanded in vitro, and also focus on a new therapeutic venue that utilises hMSCs as delivery vehicles in innovative new cancer treatments.


Özet

Derleme

Human Mesenchymal Stem Cells in Cancer Therapy

Review Begell House,Inc./Critical Reviews in Eukaryotic Gene Expression, Volume 26, Issue 1, 2016, Pages 41-48

Abstract

Human mesenchymal stem cells (hMSCs) have the ability to differentiate into several tissue types. Their use in cancer therapeutics or as therapeutic delivery vehicles has significant potential, particularly in their exosome/microvesicle–mediated tissue regeneration abilities. In this review, the potential use of hMSCs in cancer therapy is discussed.


Özet

The route to HPV-Associated Neoplastic Transformation,A review of the literature

Review Begell House,Inc./Critical Reviews in Eukaryotic Gene Expression, Volume 26, Issue 1, 2016, Pages 27 - 39

Abstract

Human papillomaviruses (HPVs); small, non-enveloped viruses with double stranded circular DNA; are believed to play a role in the progression of cancer. However, the exact mechanisms are not well established. The interference of HPV proteins, especially E6 and E7, with the cell cycle are considered to be the main pathway. It is still questioned whether the expression of these proteins or the viral load is more important in the neoplastic transformation. Furthermore, HPV is believed to adapt mechanisms to evade the host cells’ immune system and the persistent HPV infection may also play a role in oncogenic transformation by causing genomic instability and local immune suppression. These factors may cause accumulation of genomic alterations within the host cell and integration of the viral genome into the host genome. In the recent years, epigenetic modifications, such as methylation, are also believed to take a part in the neoplastic transformation. All these alterations to the genome may be favourable for the development of cancer. In this communication, we highlight the association of HPV in neoplastic transformation and progression of cancer.


Özet

The role of human papillomaviruses in cancer progression

Review Journal of Cancer Metastasis and Treatment.Published by OAE Publishing Inc., Volume -, Issue 2, 2016, Pages 201-13

Abstract

The importance of human papillomavirus(HPV)infection and its role in the progress of cancer have been widely evaluated.The understanding of HPV association with certain cancers,such as cervical cancer,is very well established.A big step forward in the prevention of HPV associated cancers with the use of early detection by screening strategies has also been taken.In the last decade,development of HPV vaccination has reduced the number of cases in HPV infections and infection induced cancers.In this report,we review the HPV pathogenesis and highlight the mechanism of HPV involvement in cancer development.


Özet

Double-Faced Role of Human Mesenchymal Stem Cells and their Role in Cancer Therapy and challenges

Review Bentham Science Publishers/Current stem cell research and therapy, Volume 11, Issue 4, 2016, Pages 343-351

Abstract

Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant importance in cancer therapies as well as a large number of degenerative disease therapies due to their homing abilities. However, these cells may undergo spontaneous transformation leading to them bypassing naturally built-in cell controls that could lead to senescence and carcinogenesis. Therefore, although MSCs have great potential for cancer therapy, they also risk the development of cancer, which provides them with double-faced characteristics for both cancer development and therapy. The potential use of hMSCs in therapeutics from the aspect of in vitro expansion of hMSCs and telomere dynamic is discussed.


Özet

Currrent Teaching

  • 2019 Bahar

    CURRENT DEVELOPMENTS AND MOLECULAR BIOLOGY

    Moleküler biyolojideki yenilekleri öğrencilere aktarmak

Teaching History

  • 2017 BAHAR

    MOLECULAR CYTOGENETIC APPROACHES AND APPLICATIONS TO DISEASE

    --

  • 2018 BAHAR

    GRADUATION PROJECT 2

    -

  • 2015 GÜZ

    MOLECULAR GENETIC DISEASES AND DIAGNOSTIC TOOLS

    --

  • 2017 BAHAR

    PROJECT WORK

    -

  • 2015 BAHAR

    SEMINAR

    -

  • 2014 GÜZ

    CHEMISTRY FOR BIOLOGICAL SCIENCES

    .

  • 2016 BAHAR

    MOLECULAR PATHOGENESIS OF CANCER AND AGING

    -

  • 2016 BAHAR

    MOLECULAR CELL BIOLOGY

    Moleküler biyolojideki temel kavram ve konuları anlatmak

  • 2015 BAHAR

    THESIS WORK

    --

  • 2019 GÜZ

    PROJECT WORK

    -

  • 2017 GÜZ

    SEMINAR

    -

  • 2017 GÜZ

    MEDICAL GENETICS MOLECULAR METHODS AND APPLICATIONS

    --

  • 2018 BAHAR

    GRADUATION PROJECT 1

    -

  • 2016 BAHAR

    GRADUATION PROJECT I

    Bitirme tezine hazırlık

  • 2016 GÜZ

    BIOTECHNOLOGY

    -

  • 2015 GÜZ

    GENES AND INHERITANCE

    -

  • 2017 GÜZ

    ADVANCED BIOTECHNOLOGICAL METHODS

    -

  • 2018 GÜZ

    ADVANCED BIOTECHNOLOGICAL METHODS

    -

  • 2016 GÜZ

    CANCER GENETICS

    -

  • 2015 BAHAR

    MOLECULAR CELL BIOLOGY

    -

  • 2015 GÜZ

    SEMINAR

    Seçilen konuda literatür araştırması yaparak kişişel görüşleriyle birlikte bilimsel tartışma yetisini geliştirmek

  • 2016 GÜZ

    THESIS WORK

    --

  • 2017 GÜZ

    PRINCIPLES OF MEDICAL GENETICS

    -

  • 2018 GÜZ

    PRINCIPLES OF MEDICAL GENETICS

    -

  • 2016 GÜZ

    MEDICAL GENETICS- Genetics of common disorders

    -

  • 2017 GÜZ

    GENERAL AND CELL BIOLOGY I

    THE MAIN AIM OF COURSE IS TO REPRESENT THE PLACE AND THE IMPROTANCE OF BIOLOGY IN SCIENTIFIC CONTINUUM.

  • 2015 GÜZ

    CYTOGENETIC DISORDERS AND LABORATORY TESTS

    -

  • 2016 GÜZ

    POPULATION GENETICS AND GENETIC EPIDEMIOLOGY

  • 2018 GÜZ

    SEMINAR

    Seçilen konuda literatür araştırması yaparak kişişel görüşleriyle birlikte bilimsel tartışma yetisini geliştirmek

  • 2016 BAHAR

    BASIC PRINCIPLES OF GENETICS

    -

  • 2016 BAHAR

    THESIS WORK

    --

  • 2017 GÜZ

    -

    -

  • 2017 GÜZ

    GENERAL AND CELL BIOLOGY

    -

  • 2017 GÜZ

    GENETIC COUNSELLING II

    -

  • 2017 BAHAR

    CURRENT DEVELOPMENTS IN MOLECULAR BIOLOGY

    Moleküler biyolojideki yenilekleri öğrencilere aktarmak

  • 2016 GÜZ

    BIOTECHNOLOGY TECHNIQUES

    THE AIM IS TO TEACH THE TECHNIQUES USED IN THE STUDY OF BIOMOLECULES,ESPECIALLY NUCLEIC ACIDS AND PROTEİNS.

  • 2017 BAHAR

    SPECIAL APPLICATIONS IN MOLECULAR BIOLOGY AND GENETICS

    -

  • 2017 GÜZ

    MEDICAL GENETICS- Genetics of common disorders

    -

  • 2018 GÜZ

    MEDICAL GENETICS- Genetics of common disorders

    -

  • 2017 GÜZ

    GENE REGULATION AND EPIGENETICS

    -

  • 2017 GÜZ

    GENERAL AND CELL BIOLOGY

    -

  • 2016 BAHAR

    BASIC PRINCIPLES OF GENETICS

    Genetikteki temel kavram ve konuları anlatmak

  • 2016 GÜZ

    GENES AND DEVELOPMENT AND INHERITANCE

  • 2016 BAHAR

    MOLECULAR CELL BIOLOGY

    -

  • 2016 BAHAR

    PRINCIPLES OF MEDICAL GENETICS

    -

  • 2015 GÜZ

    MEDICAL GENETICS- Genetics of common disorders

    -

  • 2014 GÜZ

    IT AND NUMERACY SKILLS FOR MOLECULAR BIOLOGIST

  • 2017 GÜZ

    CANCER AND AGING

    -

  • 2016 GÜZ

    GENETIC COUNSELLING II

    -

  • 2016 BAHAR

    SEMINAR

    Seçilen konuda literatür araştırması yaparak kişişel görüşleriyle birlikte bilimsel tartışma yetisini geliştirmek

  • 2017 BAHAR

    GRADUATION PROJECT I

    Bitirme tezine hazırlık

  • 2018 BAHAR

    GRADUATION PROJECT I

    Bitirme tezine hazırlık

  • 2016 GÜZ

    ADVANCED BIOTECHNOLOGICAL METHODS

    -

  • 2015 BAHAR

    BASIC PRINCIPLES OF GENETICS

    Genetikteki temel kavram ve konuları anlatmak

  • 2017 GÜZ

    THESIS WORK

    --

  • 2018 GÜZ

    THESIS WORK

    --

  • 2015 BAHAR

    GENETIC COUNSELLING II

    -

  • 2016 GÜZ

    MEDICAL GENETICS MOLECULAR METHODS AND APPLICATIONS

    --

  • 2016 BAHAR

    MOLECULAR CYTOGENETIC APPROACHES AND APPLICATIONS TO DISEASE

    --

  • 2016 BAHAR

    HUMAN GENETICS AND GENOMICS

    İnsan genetiği ve genomik hakkında detaylı bilgi vermek

  • 2019 GÜZ

    CANCER AND MOLECULAR PATHOGENESIS OF AGING

    -

  • 2016 BAHAR

    HUMAN GENETICS AND GENOMICS

    Aims to teach human genetics and genomics in more specialized manner

  • 2016 GÜZ

    GENETIC COUNSELLING

  • 2017 BAHAR

    QUALIFICATION EXAM PREPARATION PERIOD

    -

  • 2016 BAHAR

    METHODS AND APPLICATIONS IN BIOTECHNOLOGY

    --

  • 2016 GÜZ

    METHODS AND APPLICATIONS IN BIOTECHNOLOGY

    --

  • 2014 GÜZ

    INTRODUCTION TO PHYSICS

    --

  • 2019 GÜZ

    ADVANCED BIOTECHNOLOGICAL METHODS

    -

  • 2015 BAHAR

    PRINCIPLES OF MEDICAL GENETICS

  • 2016 GÜZ

    SEMINAR

    Seçilen konuda literatür araştırması yaparak kişişel görüşleriyle birlikte bilimsel tartışma yetisini geliştirmek

  • 2018 BAHAR

    THESIS WORK

    -

  • 2017 GÜZ

    METHODS AND APPLICATIONS IN BIOTECHNOLOGY

    --

  • 2018 BAHAR

    CURRENT DEVELOPMENTS AND MOLECULAR BIOLOGY

    Moleküler biyolojideki yenilekleri öğrencilere aktarmak

  • 2019 GÜZ

    MOLECULAR PATHOGENESIS OF AGING AND CANCER

    -

  • 2015 BAHAR

    PROJECT WORK

    -

  • 2018 BAHAR

    SEMINAR

    -

  • 2019 GÜZ

    THESIS WORK

    -

  • 2016 BAHAR

    CURRENT DEVELOPMENTS AND MOLECULAR BIOLOGY

    Moleküler biyolojideki yenilekleri öğrencilere aktarmak

  • 2017 BAHAR

    SPECİAL APPLİCATİONS İN MOLECULAR BİOLOGY AND GENETİCS

    -

  • 2016 GÜZ

    SEMINAR

    -

  • 2019 GÜZ

    SEMINAR

    -

  • 2016 GÜZ

    MEDICAL GENETICS

    -

  • 2018 GÜZ

    QUALIFICATION EXAM PREPARATION PERIOD

    -

  • 2018 GÜZ

    METHODS AND APPLICATIONS IN BIOTECHNOLOGY

    --

  • 2017 BAHAR

    CURRENT DEVELOPMENTS AND MOLECULAR BIOLOGY

    Moleküler biyolojideki yenilekleri öğrencilere aktarmak

  • 2017 BAHAR

    GRADUATION PROJECT II

    bitirme tezi yazılacak

  • 2018 BAHAR

    GRADUATION PROJECT II

    bitirme tezi yazılacak

  • 2016 GÜZ

    GENES AND INHERITANCE

    THE AIM IS TO TEACH THE INHERITANCE PATTERNS OF DISEASES AND PROVIDE EXAMPLES OF GENETIC DISORDERS.

  • 2016 GÜZ

    TERATOLOGY in PRENATAL DEVELOPMENT and COUNSELLING

    -

  • 2015 GÜZ

    MEDICAL GENETICS MOLECULAR METHODS AND APPLICATIONS

    --

  • 2015 GÜZ

    METHODS AND APPLICATIONS IN BIOTECHNOLOGY

    --

  • 2019 GÜZ

    METHODS AND APPLICATIONS IN BIOTECHNOLOGY

    -

  • 2014 GÜZ

    GENERAL AND CELL BIOLOGY

    -

  • 2017 BAHAR

    MOLECULAR PATHOGENESIS OF CANCER AND AGING

    -

  • 2016 BAHAR

    LABORATORY SAFETY AND TECHNIQUES

    -

  • 2016 GÜZ

    GENES AND INHERITANCE

    -

  • 2014 GÜZ

    ACADEMIC ENGLISH AND WRITING SKILLS

  • 2016 BAHAR

    THESIS

    --

  • 2015 BAHAR

    PRINCIPLES OF MEDICAL GENETICS

    -

  • 2017 GÜZ

    AGING

    -

  • 2018 GÜZ

    AGING

    -

  • 2018 BAHAR

    CURRENT DEVELOPMENTS IN MOLECULAR BIOLOGY

    Moleküler biyolojideki yenilekleri öğrencilere aktarmak

  • 2014 BAHAR

    BASIC PRINCIPLES OF GENETICS

    -

  • 2015 BAHAR

    BASIC PRINCIPLES OF GENETICS

    -

  • 2015 GÜZ

    PROJECT WORK

    -

  • 2017 BAHAR

    SEMINAR

    Seçilen konuda literatür araştırması yaparak kişişel görüşleriyle birlikte bilimsel tartışma yetisini geliştirmek

  • 2015 GÜZ

    CYTOGENETIC APPLICATIONS

  • 2015 BAHAR

    ESSENTIALS OF MEDICAL GENETICS

  • 2019 GÜZ

    AGING

    -

  • 2016 BAHAR

    GRADUATION PROJECT II

    bitirme tezi yazılacak

  • 2017 GÜZ

    MOLECULAR GENETIC DISEASES AND DIAGNOSTIC TOOLS

    --

  • 2016 BAHAR

    MEDICAL GENETICS MOLECULAR METHODS AND APPLICATIONS

    --

  • 2015 GÜZ

    GENES AND INHERITANCE

    THE AIM IS TO TEACH THE INHERITANCE PATTERNS OF DISEASES AND PROVIDE EXAMPLES OF GENETIC DISORDERS.

  • 2016 BAHAR

    MOLECULAR GENETIC DISEASES AND DIAGNOSTIC TOOLS

    --

  • 2015 BAHAR

    MOLECULAR CELL BIOLOGY

    Moleküler biyolojideki temel kavram ve konuları anlatmak

  • 2017 GÜZ

    TERATOLOGY in PRENATAL DEVELOPMENT and COUNSELLING

    -

  • 2017 GÜZ

    THESIS

    --

  • 2017 BAHAR

    MOLECULAR PATOGENESİS OF CANCER AND AGİNG

    -

  • 2017 GÜZ

    PROJECT WORK

    -

  • 2018 GÜZ

    PROJECT WORK

    --

  • 2015 BAHAR

    SEMINAR

    Seçilen konuda literatür araştırması yaparak kişişel görüşleriyle birlikte bilimsel tartışma yetisini geliştirmek

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