Work Experience

  • Todate 1999

    Prof. Dr., Anabilim Dalı Başkanı

    Mersin Üniversitesi Tıp Fakültesi, Tıbbi Farmakoloji

Education & Training

  • Ph.D. 1996

    Farmakoloji

    Çukurova

  • Master1994

    Farmakoloji

    Çukurova

  • Bachelor1990

    Eczacılık

    Ege

Honors, Awards and Grants

  • 2005
    2003-2004 yılları Novartis Farmakoloji Dalı Araştırma Ödülleri Birinciliği
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  • 2003
    Türk Fizyolojik Bilimler Derneği Genç Araştırmacı Ödülleri Birinciliği
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  • 2002
    Türkiye Bilimler Akademisi (TÜBA) Üstün Başarılı Genç Bilim İnsanı Ödülü
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  • 1990
    Ege Üniversitesi Eczacılık Fakültesi 1990 yılı mezunları Birinciliği
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  • 2009
    2007-2008 yılları Novartis Farmakoloji Dalı Araştırma Ödülleri Birinciliği
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  • 2001
    1999-2000 yılları Novartis Farmakoloji Dalı Araştırma Ödülleri Birinciliği
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Research Projects

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    Sıçan koroner mikrovasküler endotel hücre kültürlerinde nitrik oksidin Rho-kinaz enzim ekspresyonu üzerine etkisi. TÜBİTAK SBAG-2711, 2004 (Yürütücü) (Tamamlandı).

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    Nitrik oksidin preadipositlerde (3T3-L1) proliferasyon, diferansiyasyon ve aktin hücre iskeleti organizasyonu üzerine etkileri: Rho/Rho-kinaz yolağının olası rolü. TÜBİTAK SBAG-110S451, 2011 (Yürütücü) (Tamamlandı).

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    Preadipositlerde (3T3-L1) estrojen ve progesteronun adipositokin, salıverilmesi ve diferansiyasyon üzerine etkisi: Rho/Rho-kinaz yolağının olası katkısı” TÜBİTAK SBAG-109S126, 2009 (Yürütücü) (Tamamlandı).

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    Erektil Fonksiyonda Hsp90’ın Rolü. TÜBİTAK SBAG-, 2010 (Danışman) (Tamamlandı).

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    Absans epilepsisinin patofizyolojisinde Rho/Rho-kinaz yolağının olası rolü. TÜBİTAK SBAG-113S221, 2013 (Yürütücü) (Tamamlandı).

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    Sıçan koroner mikrovasküler endotel hücre kültüründe estradiol ile oluşturulan Rho-kinaz Enzim up-regülasyonun özelliklerinin araştırılması. TÜBİTAK SBAG-108S421, 2009 (Yürütücü) (Tamamlandı).

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Original Article -, Volume -, Issue -, 2000, Pages -

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Özet

8. Kurt AH, Tiftik RN, Un I, Ulker S, Büyükafşar K. G protein-coupled estrogen receptor1 (GPER1) may mediate Rho-kinase (ROCK-2) up-regulation in coronary endothelial cells. Endocr Regul., 47: 75-84, 2013.

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39. Büyükafşar K., Göçmen C., Seçilmiş A., Göktürk S., Karataş Y., Kalyoncu NI. Evidence that the nitrergic neurotransmitter and endothelium-derived relaxing factor might be S- nitrosothiols in the isolated mouse corpus cavernosum. Acta Med. Okayama, 53: 209-215, 1999.

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15. Tiftik RN, Erol, A., Cinar MG, Kubat H., Ark M, Ulker S, Büyükafşar K. Nitric oxide does not downregulate Rho-kinase (ROCK-2) expression in rat coronary endothelial cells. J. Cardiovasc. Pharmacol., 51: 140-147, 2008.

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16. Turna B., Cinar MG., Canda AE., Orhan EC., Tiftik NR., Nazli O., Büyükafşar K. Role of Rho-kinase in contractions of ureters from rabbits with unilateral ureteric obstruction. BJU Int., 100: 1166-1171, 2007.

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25. Ark M., Özveren E., Yazıcı G., Büyükafşar K., Arıkan O., Kubat H., Songu-Mize E. Effects of HA-1077 and Y-27632 two Rho-kinase inhibitors in the human umbilical artery. Cell Biochem. Biophys., 41: 331-342, 2004.

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24. Büyükafşar K., Arıkan O., Ark M., Kubat H., Özveren E. Upregulation of Rho kinase (ROCK-2) expression and enhanced contraction to endothelin-1 in the mesenteric artery from lipopolysaccharide-treated rats. Eur. J. Pharmacol., 495: 211-217, 2004.

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14. Baumhakel M., Schlimmer N., Büyükafşar K., Arikan O., Böhm M. Nebivolol, but not metoprolol, improves endothelial function of the corpus cavernosum in apolipoprotein e-knockout mice. J. Pharmacol., Exp. Ther., 325: 818-823, 2008.

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40. Öğülener N., Yaktubay N., Büyükafşar K., Dikmen A., Baysal F. Some properties of the photorelaxation induced by UV light and possible role of nitric oxide in the isolated mouse gastric fundal smooth muscle. As. Pas. J. Pharmacol., 11: 109-120, 1996.

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17. Seçilmiş MA., Ozü OY., Emre M., Büyükafşar K., Kiroglu OE, Ertuğ P, Karataş Y, Onder S, Singirik E. Urocortin induces endothelium-dependent vasodilatation and hyperpolarization of rat mesenteric arteries by activating Ca2+-activated K+ channels. Tohoku J Exp Med., 213: 89-98, 2007.

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7. Kurt AH, Büyükafşar K. Vasoconstriction induced by G1, a G-protein-coupled oestrogen receptor1 (GPER-1) agonist, in the isolated perfused rat kidney. Eur J Pharmacol., 702: 71-78, 2013.

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37. Nelli S., Hillen M., Büyükafşar K., Martin W. Oxidation of nitroxyl anion to nitric oxide by copper ions. Br. J. Pharmacol., 131: 356-362, 2000.

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13. İnan SY., Büyükafşar K. Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil in mice. Br. J. Pharmacol., 155: 44-51, 2008.

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11. Yurtsever AS., Pektaş M., Özkur M., Ün İ., Erenmemişoğlu A., Büyükafşar K. Proton pump inhibitors omeprazole, lansoprazole and pantoprazole induce relaxation in the rat lower oesophageal sphincter. J Pharm Pharmacol., 63: 1295-1300, 2011.

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30. Büyükafşar K., Levent A. Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus. Biochem. Biophys. Res. Commun., 303: 777-781, 2003.

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33. Yazar A., Polat G., Ün İ., Levent A., Kaygusuz A., Çamdeviren H., Büyükafşar K. Effects of glibenclamide, metformin and insulin on the incidence and latency of death by oubain-induced arrhythmias in mice. Pharmacol. Res., 45: 183-187, 2002.

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9. Ün İ, Kurt AH, Batus A, Büyükafşar K. Alfacalcidol suppresses ?-receptor–mediated vasoconstriction via an endothelium dependent mechanism. Turk J Med Sci., 43: 238-244, 2013.

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20. Yazar A, Büyükafpar K, Polat G, Pata C, Kanyk A, Tiftik EN, Bağdatoğlu O. The urinary 5-hydroxyindole acetic acid and plasma nitric oxide levels in irritable bowel syndrome: a preliminary study. Scott Med J. 50: 27-29, 2005.

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18. Büyükafşar K., Yalçın İ., Kurt A. H., Tiftik RN., Şahan-Fırat S., Aksu F. Rho-kinase inhibitor, Y-27632, has an antinociceptive effect in mice. Eur. J. Pharmacol., 541: 49-52, 2006.

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2. Pektaş M, Kurt AH, Ün İ, Tiftik RN, Büyükafşar K. Effects of 17ß-estradiol and progesterone on the production of adipokines in differentiating 3T3-L1 adipocytes: Role of Rho-kinase. Cytokine. 72(2):130-134, 2015.

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1. Kurt AH, Macit E, Uzbay T, Buyukafsar K. Effects of ethanol withdrawal on the activity of rho-kinase in rat brain. Bratisl Lek Listy. 116(8):490-493, 2015.

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21. Şahan-Fırat S., Tiftik RN., Nacak M., Büyükafşar K. Rho kinase expression and its central role in the ovine gallbladder elicited by a variety of excitatory stimuli. Eur. J. Pharmacol., 528: 169-175, 2005.

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19. Büyükafşar K., Akça T., Tiftik RN., Şahan-Fırat S., Aydın S. Contribution of Rho-kinase in human gallbladder contractions. Eur. J. Pharmacol., 540: 162-167, 2006.

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34. Uçar-Ertuğ P., Büyükafşar K., Karabal-Kumcu E., Göçmen C., Seçilmiş A., Şingirik E., Dikmen A., Baysal F. Effects of some divalent cations on the nitrergic relaxations in the mouse corpus cavernosum. Fundam. Cli. Pharmacol., 15: 343-348, 2001.

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5. Seçilmiş M, Ozü O, Kıroğlu O, Singirik E, Büyükafşar K. The production of vasoconstriction-induced residual NO modulates perfusion pressure in rat mesenteric vascular bed. Perfusion. 29(6): 488-495, 2014.

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4. Çayan S, Saylam B, Tiftik N, Ünal ND, Apa DD, Efesoy O, Çimen B, Bozlu M, Akbay E, Büyükafşar K. Rho-kinase levels in testicular ischemia-reperfusion injury and effects of its inhibitor, Y-27632, on oxidative stress, spermatogenesis, and apoptosis. Urology. 83(3): 675.e13-18, 2014.

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23. Levent A., Büyükafşar K. Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter. Br. J. Pharmacol., 143: 431-437, 2004.

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12. Güldali O., Savcı V., Büyükafşar K. CDP–choline induced contractions in the mouse gastric fundus through purinoceptors and Rho/Rho–kinase signalling. Life Sci., 88: 473-479, 2011.

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6. Tiftik RN, Başkurt OK, Kul S, Büyükafşar K. The functional significance of the rho/rho-kinase pathway in human erythrocytes.Turk J Haematol., 31(2): 168-174, 2014.

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3. Tiftik RN, Başkurt OK, Kul S , Büyükafşar K. The functional significance of the rho/rho-kinase pathway in human erythrocytes. Turk J Haematol. 31(2):168-174, 2014.

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29. Büyükafşar K., Ün İ. Effects of the Rho-kinase inhibitors, Y-27632 and fasudil on the corpus cavernosum from diabetic mice. Eur. J. Pharmacol., 472: 235-238, 2003.

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35. Büyükafşar K., Yazar A., Düşmez D., Öztürk H., Polat G., Levent A. Effect of trapidil, an antiplatelet and vasodilator agent on gentamicin-induced nephrotoxicity in rats. Pharmacol. Res., 44:321-328, 2001.

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38. Büyükafşar K., Demirel-Yılmaz E., Göçmen C., Dikmen A. Depletion and restoration of the putative photosensitive materials store yielding nitric oxide in the isolated mouse gastric fundus. J. Pharmacol. Exp. Ther., 290: 768-773, 1999.

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10. Ün İ., Kurt AH., Büyükafşar K. Hyperosmolar glucose induces vasoconstriction through Rho/Rho-kinase pathway in the rat aorta. Fundam Clin Pharmacol. 27: 244-251, 2013.

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31. Büyükafşar K., Levent A., Ün İ., Ark M., Arıkan O., Özveren E. Mediation of nitric oxide from photosensitive stores of the rabbit corpus cavernosum. Eur. J. Pharmacol., 459: 263-267, 2003.

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27. Karataş Y., Seçilmiş MA., Karayaylalı İ., Doran F., Büyükafşar K., Şingirik E., Sağlıker Y., Dikmen A. Effect of tempol (4-hydroxy tempo) on gentamicin-induced nephrotoxicity in rats. Fundam. Cli. Pharmacol., 18: 79-83, 2004.

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36. Büyükafşar K., Nelli S., Martin W. Formation of nitric oxide from nitroxyl anion: Role for quinone and ferricytochrome c. Br. J. Pharmacol., 132: 165-172, 2001.

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28. Büyükafşar K., Levent A., Ark M. Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens. Br. J. Pharmacol., 140: 743-749, 2003.

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26. Büyükafşar K., Arıkan O., Ark M., Seçilmiş A., Ün İ., Şingirik E. Rho-kinase expression and its contribution to the control of perfusion pressure in the isolated rat mesenteric vascular bed. Eur. J. Pharmacol., 485: 265-268, 2004.

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32. Cinel İ., Büyükafşar K., Cinel L., Polat A., Atıcı Ş., Tamer L., Oral U. The role of poly (ADP-Ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis. Pharmacol. Res., 46: 119-127, 2002.

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22. Köksel O., Yıldırım, Ç, Kubat, H, Tiftik, N, Tamer, L, Cinel, L, Kaplan, MB, Değirmenci, U, Özdülger, A, Büyükafşar K. Rho-kinase (ROCK-1 and ROCK-2) upregulation in oleic acid-induced lung injury and its restoration by Y-27632. Eur. J. Pharmacol., 510: 135-142, 2005.

Currrent Teaching

Teaching History

  • 2016 GÜZ

    EMERGENCY MEDICAL NURSING SEMINAR

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  • 2015 BAHAR

    THE ART OF WRITING A SCIENTIFIC ARTICLE

  • 2016 GÜZ

    METHODS OF PREPARATION OF A SCIENTIFIC PROJECT AND WRITING A SCIENTIFIC ARTICLE

  • 2017 BAHAR

    Seminar of Child's Health And Disease Nursing

  • 2016 GÜZ

    Seminar of Child's Health And Disease Nursing

  • 2016 GÜZ

    Seminar of Public Health Nursing

  • 2015 GÜZ

    PHARMACOLOGY

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  • 2016 GÜZ

    Seminar of Fundamentals of Nursing

  • 2016 GÜZ

    Seminar of Medical Nursing

  • 2015 BAHAR

    BILIMSEL PROJE HAZIRLAMA YÖNTEMLERI

  • 2015 GÜZ

    PHARMACOLOGY FOR NURSES

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  • 2016 GÜZ

    Seminar of Mental Health and Psychiatric Nursing

  • 2016 BAHAR

    SEMINAR

    .

  • 2016 GÜZ

    SEMINAR

    .

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